P. yoelii circumsporozoite protein plasmid DNA

P. yoelii circumsporozoite protein plasmid DNA is a preclinical DNA plasmid vaccine encoding the circumsporozoite protein (CSP) of the rodent malaria parasite Plasmodium yoelii. Originally developed in the 1990s by researchers at the Naval Medical Research Center and Vical, it serves as a widely used model antigen in malaria vaccine research. The vaccine is designed to induce protective humoral and cellular immune responses, specifically CD8+ T-cell-mediated immunity, against sporozoite challenge in rodent models. It is frequently utilized in heterologous prime-boost regimens, such as the 'prime-and-trap' strategy developed at the University of Washington, where DNA priming is followed by trapping with radiation-attenuated sporozoites to generate liver-resident memory T cells.

Other names

1012/TPA-PyCSPPlasmodium yoelii circumsporozoite protein plasmid DNAnkCMVintPyCSP.1pCSPpPyCSPPyCSP DNA vaccinePyCSP plasmid DNA