p1075

P1075 is a small molecule vasodilator classified as an ATP-sensitive potassium channel opener (KATP channel opener or KATPCO)[1][2][6]. It induces relaxation of vascular smooth muscle by activating KATP channels, primarily by binding to sulfonylurea receptors SUR2A and SUR2B with high affinity (Kd of 17 nM and 3 nM, respectively)[1]. This mechanism leads to peripheral vasodilation, reduced blood pressure, and increased blood flow[2]. P1075 has been used as a research tool in cardiovascular studies and exhibits high potency (EC50 rat aorta relaxation = 7.5 nM)[1]. No approved clinical indications or marketed pharmaceutical products containing P1075 are known, and it is predominantly distributed by research chemical suppliers[1][6].

Other names

3-pyridinyl-guanidineN-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidine