P12FR2

**P12FR2** is a 2′-fluoropyrimidine-modified RNA aptamer specifically designed to bind the human pancreatic adenocarcinoma up-regulated factor (PAUF), which is overexpressed in pancreatic ductal adenocarcinoma (PDAC). P12FR2 exhibits nanomolar affinity for PAUF and effectively inhibits PAUF-induced migration of pancreatic cancer cells (PANC-1) in vitro. In preclinical xenograft mouse models, intraperitoneal administration of P12FR2 significantly reduced tumor growth by up to 60% without notable systemic toxicity. The aptamer is being explored as a potential targeted therapy for pancreatic cancer, leveraging the advantages of aptamers such as high specificity, rapid synthesis, and modifiability for targeted delivery[3][5].