p14ARF minimal domain peptide

p14ARF minimal domain peptide is a cell-penetrating peptide therapeutic in preclinical development at Washington University in St. Louis for the treatment of non-small cell lung cancer (NSCLC). The peptide consists of a 10-amino acid minimal functional domain of the p14ARF tumor suppressor protein linked to an arginine-rich cell-penetrating peptide (CPP) tail. It is designed to enter tumor cells and restore the tumor suppressor functions of p14ARF, which is frequently mutated or deleted in NSCLC. Mechanistically, the peptide mimics wild-type p14ARF by interacting with MDM2 (mouse double minute 2 homolog) to prevent MDM2-mediated degradation of p53, thereby stabilizing p53 and promoting cell death and antiproliferative effects. It also interacts with nucleophosmin (NPM1) to regulate ribosome biogenesis.

Other names

p14ARF CPPp-14ARF CPPp 14ARF CPPp14ARF cell-penetrating peptidep-14ARF cell-penetrating peptidep 14ARF cell-penetrating peptidep14ARF-derived peptidep-14ARF-derived peptidep 14ARF-derived peptide