P2Y1 shRNA

P2Y1 shRNA is a gene-silencing therapeutic candidate designed to knock down the expression of the P2Y1 purinergic receptor (P2RY1). In glioblastoma (GBM) research, it is utilized to investigate and inhibit the purinergic signaling pathway driven by extracellular ATP and ADP. By reducing P2Y1 levels, this short hairpin RNA (shRNA) inhibits tumor cell-autonomous calcium oscillations, which are critical for GBM growth, sphere formation, and invasion. Preclinical studies using patient-derived glioblastoma cells have demonstrated that P2Y1 knockdown significantly reduces both spontaneous and ligand-induced calcium waves, suggesting that targeting this Gq protein-coupled receptor via RNA interference could be a viable strategy to limit tumor progression in aggressive brain malignancies.

Other names

shRNA knockdown of P2Y1P2RY1 shRNAP-2RY1 shRNAP 2RY1 shRNA