P300i

P300i (p300 inhibitor) refers to a class of small molecules that inhibit the histone acetyltransferase (HAT) activity of the p300 protein (also known as EP300). In the context of the provided research, P300i specifically refers to a tool compound, likely the small molecule **C646**, used to modulate the function of FoxP3+ regulatory T cells (Tregs). p300 is a critical co-activator that acetylates FoxP3, thereby increasing its protein stability and transcriptional activity. Inhibition of p300 leads to reduced Treg suppressive capacity and altered Treg distribution. In aged mouse models of multiple sclerosis (EAE), treatment with a p300 inhibitor has been shown to mitigate disease severity by preventing the accumulation of pathogenic Tregs in the choroid plexus and facilitating the entry of reparative, myelin-specific Tregs into the central nervous system to repair neuroinflammatory damage.

Other names

p300 inhibitorp-300 inhibitorp 300 inhibitorEP300 inhibitorEP-300 inhibitorEP 300 inhibitorC646C-646C 646