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P311
- Development stage
- Preclinical
- Modality
- Peptides, Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
P311, also known as Neuronal regeneration related protein (NREP) or Neural protein 3.1, is an 8 kDa intracellular protein/peptide that plays a significant role in tissue repair and regeneration. It promotes angiogenesis, re-epithelialization, and M2 macrophage polarization, which are crucial for effective wound healing. Its functions are mediated through interactions with several signaling pathways, including the TGF-βRII-Smad, Akt, and mTOR pathways, and by upregulating factors like the IL-4 receptor and vascular endothelial growth factor (VEGF). P311 is being investigated as a therapeutic agent, particularly in formulations like microspheres and micelles, to enhance wound healing.
- Other names
- Neuronal regeneration related proteinNREPNeural protein 3.1
02
Targets
HPRT1 (Hypoxanthine-guanine phosphoribosyltransferase)CCL21 (Chemokine (C-C motif) ligand 21)
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