Drug intelligence / Profile preview

p392wt

Development stage
Preclinical
Lead developer
Universität Leipzig
Modality
Peptides
01

Overview

p392wt: sourced facts only. name: "the sequence 392 to 421, peptide p392wt, bound strongly to ACE-2 and inhibited wild-type RBD binding to ACE-2." [PMID:39996354]; target: "the sequence 392 to 421, peptide p392wt, bound strongly to ACE-2 and inhibited wild-type RBD binding to ACE-2." [PMID:39996354]; developer: "Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University, Leipzig, Germany." [PMID:39996354]; modality: "the sequence 392 to 421, peptide p392wt, bound strongly to ACE-2 and inhibited wild-type RBD binding to ACE-2." [PMID:39996354]; stage: "When studied in a SARS-CoV-2 pseudovirus assay, the p392 peptides showed a good inhibition rate of 98.8±8.1 % at a peptide concentration of ~244 μmol/L, while none of the p392 peptides inhibited antibody binding to the RBD, suggesting that peptide treatment is sufficient in the presence of anti-RBD antibodies." [PMID:39996354]

02

Targets

ACE2 (Angiotensin-converting enzyme 2)

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