P5 peptide

P5 peptide is a 21-amino acid synthetic long peptide (sequence: ELAAWCRWGFLLALLPPGIAG) derived from the rat HER2/neu protein, specifically encompassing residues 5 to 25. It is utilized as a cancer vaccine candidate designed to stimulate the immune system against HER2/neu-overexpressing malignancies. The peptide contains multiple epitopes that can be presented by both MHC class I and II molecules, thereby activating both CD8+ cytotoxic T lymphocytes and CD4+ T helper cells. In research settings, P5 is frequently pulsed onto dendritic cells and administered alongside adjuvants such as CpG-ODN and helper peptides like PADRE to enhance its immunogenicity and therapeutic efficacy by overcoming the limitations of free peptide vaccines, such as rapid degradation and weak immune stimulation.

Other names

P5 HER2/neu-derived peptiderat HER2/neu (5-25) peptide