p50-IMC

p50-IMC refers to immature myeloid cells (IMCs) that have been genetically modified or derived from a knockout model to lack the p50 subunit of the NF-κB transcription factor. In the context of glioblastoma (GBM), tumor-associated macrophages (TAMs) typically adopt an immunosuppressive M2 phenotype that promotes tumor growth. Research conducted at Virginia Tech and Johns Hopkins University demonstrates that p50-deficient IMCs are biased toward a pro-inflammatory M1 phenotype, characterized by increased expression of TNFα and IL-12b, even under M2-polarizing conditions. When adoptively transferred into orthotopic mouse models of glioblastoma, these cells localize to the tumor and transiently impair tumor growth by shifting the immune microenvironment toward a more active anti-tumor response.

Other names

NF-kB p50 knockout immature myeloid cellsp50-/- immature myeloid cells