p53 gene therapy + surgery

p53 gene therapy + surgery is a combination treatment approach that involves delivering functional p53 genes to cancer cells, typically using adenovirus vectors, followed by surgical intervention. The p53 gene is a tumor suppressor that is inactivated in approximately 50% of human cancers. The gene therapy component works by restoring p53 function in cancer cells, which can induce apoptosis (cell death), growth inhibition, or senescence in tumor cells. When combined with surgery, this approach aims to eliminate visible tumor mass while targeting microscopic disease and potentially enhancing overall treatment efficacy.

Brand names

Advexin

Other names

Ad-p53Ad-p-53Ad-p 53