p53 stealth lipid nanocapsules

P53 stealth lipid nanocapsules are an experimental nanomedicine formulation consisting of the bio-organometallic ferrocifen compound P53 encapsulated within PEGylated (stealth) lipid nanocapsules (LNCs). P53 is a ferrocene-based derivative of tamoxifen that functions as a potent producer of reactive oxygen species (ROS) through the formation of quinone methide intermediates, leading to oxidative stress and apoptosis in cancer cells. The stealth LNC delivery system, typically composed of a triglyceride core and a PEGylated surfactant shell, is designed to improve the solubility of the lipophilic P53 molecule and prolong its systemic circulation by evading the mononuclear phagocyte system. This formulation has demonstrated efficacy in preclinical models of high-grade serous ovarian carcinoma, including patient-derived xenografts (PDX) with varying oxidative phosphorylation (OXPHOS) profiles, particularly when used in combination with standard chemotherapeutic agents like carboplatin and paclitaxel.

Other names

ferrocifen P53 stealth lipid nanocapsulesP53-loaded stealth lipid nanocapsulesP-53-loaded stealth lipid nanocapsulesP 53-loaded stealth lipid nanocapsules