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p66Shc siRNA
- Development stage
- Preclinical
- Lead developer
- Chungnam National University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intraarticular, Intrathecal
01
Overview
p66Shc siRNA is a small interfering RNA (siRNA) designed to silence the expression of p66Shc, a redox-sensitive and pro-apoptotic adaptor protein encoded by the SHC1 gene. p66Shc plays a key role in regulating mitochondrial reactive oxygen species (ROS) generation, oxidative stress, and apoptosis. In preclinical studies, p66Shc siRNA has been encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles to improve delivery and stability. This therapeutic approach is being investigated by researchers at Chungnam National University for various indications, including N-methyl-D-aspartate (NMDA)-induced spasms (infantile spasms), osteoarthritis, and neuropathic pain, where it has demonstrated efficacy in reducing oxidative stress, mitochondrial dysfunction, and neuroinflammation.
- Other names
- p66shc siRNAp-66shc siRNAp 66shc siRNAp66shc siRNA-PLGA NPsp-66shc siRNA-PLGA NPsp 66shc siRNA-PLGA NPsp66shc siRNA-encapsulated PLGA nanoparticlesp-66shc siRNA-encapsulated PLGA nanoparticlesp 66shc siRNA-encapsulated PLGA nanoparticlesp66shc-siRNA-loaded nanoparticlesp-66shc-siRNA-loaded nanoparticlesp 66shc-siRNA-loaded nanoparticles
02
Targets
NFKB2 (NF-κB2)
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