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P722 stealth lipid nanocapsules
- Development stage
- Preclinical
- Lead developer
- Université d'Angers
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
P722 stealth lipid nanocapsules is an experimental anticancer formulation consisting of the organometallic ferrocifen compound P722 (succinimidoalkyl-ferrociphenol) encapsulated within PEGylated lipid nanocapsules. P722 belongs to the ferrocifen family, which utilizes a ferrocenyl-ene-p-phenol redox motif to generate reactive oxygen species (ROS) and induce apoptosis via the intrinsic pathway. The stealth lipid nanocapsule delivery system, featuring an oily core and a polyethylene glycol (PEG) coating, is designed to enhance tumor delivery and evade immune clearance. Preclinical studies have demonstrated efficacy in metastatic melanoma and resistant ovarian cancer models, including those with low oxidative phosphorylation (OXPHOS) profiles, by promoting immunogenic cell death and activating CD8+ T lymphocytes.
- Other names
- P722-loaded LNCsP-722-loaded LNCsP 722-loaded LNCssuccinimidoalkyl-ferrociphenol stealth lipid nanocapsules
02
Targets
CD8A (CD8 alpha/beta Coreceptor)
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