P75-NEURO

P75-NEURO is a preclinical **recombinant fusion protein biologic** being developed by **Protheragen** as a neuroprotective agent for neurological diseases. The drug is described as a dimeric fusion protein comprising the extracellular domain of the p75 neurotrophin receptor fused to the Fc fragment of human immunoglobulin. It is designed to act as a soluble decoy/antagonist of **p75 neurotrophin receptor**, thereby blocking binding and downstream neurotoxic signaling driven by ligands such as amyloid beta and proneurotrophins. Public descriptions indicate potential use in **Alzheimer's disease, ischemic stroke, traumatic brain injury, and inflammatory pain**, with mechanistic claims that it can inhibit amyloidogenic signaling, reduce tau hyperphosphorylation, and suppress inflammatory cytokine secretion. Protheragen lists the program as available for partnership and licensing and states that related patents have been filed.

Other names

p75ECD-Fcp-75ECD-Fcp 75ECD-Fcp75 neurotrophin receptor-Fc fusion proteinp-75 neurotrophin receptor-Fc fusion proteinp 75 neurotrophin receptor-Fc fusion proteinP75ECD-Fc fusion proteinP-75ECD-Fc fusion proteinP 75ECD-Fc fusion protein