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Drug intelligence / Profile preview
PACAP targeting antibody
- Development stage
- Unknown
- Lead developer
- Eli Lilly
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
PACAP-targeting antibodies are a class of monoclonal antibodies designed to bind to and inhibit pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide implicated in the pathophysiology of migraine and other pain disorders. By neutralizing PACAP, these antibodies prevent it from activating its receptors (PAC1, VPAC1, and VPAC2), thereby inhibiting vasodilation and neuroinflammatory signaling. This therapeutic class represents a novel, calcitonin gene-related peptide (CGRP)-independent pathway for migraine prevention and is also being investigated for conditions like opioid-induced hyperalgesia (OIH) and medication overuse headache (MOH).
- Other names
- anti-PACAP antibodyanti-PACAP monoclonal antibodyPACAP-targeting antibodypituitary adenylate cyclase-activating polypeptide targeting antibody
02
Targets
PACAP (Pituitary adenylate cyclase-activating polypeptide)
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