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pacifying the liver and strengthening the spleen formula
- Development stage
- Preclinical
- Lead developer
- Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pacifying the liver and strengthening the spleen formula (Shugan Jianpi Fang) is a Traditional Chinese Medicine (TCM) herbal preparation developed by researchers at The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine. It is specifically formulated to address the TCM syndrome of Liver-Qi stagnation and Spleen deficiency, which is frequently associated with neuropsychiatric conditions such as insomnia, anxiety, and depression. The formula typically comprises a combination of herbs such as Radix Bupleuri and Rhizoma Atractylodis Macrocephalae. Its mechanism of action involves the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the modulation of central neurotransmitters, including serotonin (5-HT) and gamma-aminobutyric acid (GABA), thereby improving sleep quality and stabilizing mood. It is commonly administered as an oral decoction or in granule form within hospital settings.
- Other names
- Shugan Jianpi FangShugan Jianpi decoctionShugan Jianpi formula
02
Targets
GABA-B (Gamma-aminobutyric acid receptor type B)5-HT (Serotonin receptors)GR (Glucocorticoid receptor)
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