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paclitaxel + carboplatin + trastuzumab + pertuzumab (Roche)
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A-Fudan University-breast cancer refers to Arm A of a Phase Ib/II Bayesian adaptive design umbrella study (FINEST/FASCINATE-N) conducted by Fudan University. This neoadjuvant regimen is specifically designed for patients with HER2-positive breast cancer. It consists of a chemotherapy backbone of paclitaxel (a microtubule-stabilizing agent) and carboplatin (a DNA-alkylating platinum agent), combined with dual HER2-targeted monoclonal antibodies: trastuzumab (Herceptin) and pertuzumab (Perjeta). Trastuzumab binds to domain IV of the HER2 extracellular domain to inhibit ligand-independent signaling and induce antibody-dependent cellular cytotoxicity (ADCC), while pertuzumab binds to domain II to prevent HER2 dimerization with other HER family members. This combination provides a comprehensive blockade of the HER2 pathway alongside synergistic cytotoxic effects to maximize pathological complete response (pCR) rates in the neoadjuvant setting.
- Brand names
- HerceptinPerjetaTaxolParaplatin
- Other names
- A-Fudan University-breast cancerPaclitaxel + Carboplatin + Trastuzumab + PertuzumabPCH+HP
02
Targets
DNATUBB (Tubulin (alpha and beta subunits))HER2 ECD subdomain II (Human epidermal growth factor receptor 2 dimerization interface)
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