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Drug intelligence / Profile preview
paclitaxel (Achieve Life Sciences)
- Development stage
- Discontinued
- Lead developer
- Achieve Life Sciences
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Tocosol Paclitaxel is a proprietary, vitamin E-based emulsion formulation of the taxane chemotherapy agent paclitaxel, developed by SONUS Pharmaceuticals. Utilizing the TOCOSOL drug delivery technology, this formulation creates small, stable drug particles that allow for a ready-to-use injectable emulsion. This technology was designed to eliminate the need for Cremophor EL (used in standard Taxol), thereby reducing hypersensitivity reactions and shortening infusion times from 3 hours to approximately 15 minutes. Despite receiving FDA Fast Track and Orphan Drug designations for bladder cancer, the drug's development was halted after a pivotal Phase 3 trial in metastatic breast cancer failed to demonstrate non-inferiority to weekly Taxol in terms of objective response rate.
- Other names
- TOCOSOL PaclitaxelVitamin E-emulsified paclitaxel
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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