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paclitaxel + capecitabine + oxaliplatin
- Development stage
- Phase 2
- Lead developer
- The Catholic University of Korea Seoul St. Mary’s Hospital
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intravenous, Oral
01
Overview
This combination chemotherapy regimen, developed and investigated by Seoul St. Mary's Hospital, consists of intraperitoneal (IP) paclitaxel administered alongside systemic XELOX (capecitabine and oxaliplatin). It is specifically designed as a first-line treatment for patients with advanced gastric cancer complicated by peritoneal metastasis. The rationale for IP administration is to exploit the peritoneal-plasma barrier, allowing for significantly higher concentrations of paclitaxel within the peritoneal cavity to directly target metastatic nodules while minimizing systemic side effects. Paclitaxel functions as a microtubule stabilizer, oxaliplatin as a platinum-based DNA cross-linking agent, and capecitabine as a prodrug of 5-fluorouracil that inhibits thymidylate synthase.
- Other names
- IP paclitaxel + XELOXIntraperitoneal paclitaxel plus XELOXIP-P + XELOX
02
Targets
DNATS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))
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