paclitaxel albumin-bound particles

Paclitaxel albumin-bound particles (nab-paclitaxel) is a solvent-free, nanoparticle formulation of the taxane paclitaxel. By binding paclitaxel to human albumin, the formulation eliminates the need for polyethylated castor oil (Cremophor EL), thereby reducing the risk of severe hypersensitivity reactions and allowing for higher dose intensity and shorter infusion times. The mechanism of action involves the stabilization of microtubules, inhibiting their disassembly and leading to cell cycle arrest and apoptosis. The albumin component is thought to facilitate the transport of paclitaxel across the endothelial cell layer via the gp60 receptor-mediated pathway and potentially increase accumulation in the tumor microenvironment through binding with SPARC (Secreted Protein Acidic and Rich in Cysteine). It is widely used in the treatment of metastatic breast cancer, non-small cell lung cancer, and pancreatic adenocarcinoma.

Brand names

AbraxaneKeailiAiYuan

Other names

albumin-bounded paclitaxelnab-paclitaxelnanoparticle albumin-bound paclitaxelalbumin-bound paclitaxelnanoparticle paclitaxel