paclitaxel cationic liposome

Paclitaxel cationic liposome is a **liposomal formulation of the chemotherapeutic agent paclitaxel** in which paclitaxel is encapsulated within cationic (positively charged) lipid vesicles. This specialized carrier system is designed to improve paclitaxel's aqueous solubility, enhance its delivery to tumor cells, and reduce the need for toxic solvents. Cationic liposomes enhance the association with negatively charged tumor endothelium, potentially increasing drug accumulation at tumor sites. Mechanistically, the drug acts as a microtubule stabilizer, inhibiting cell division by promoting microtubule assembly and blocking depolymerization, ultimately leading to apoptosis in proliferating cancer cells. Several formulations, including those with improved lipid tails and PEGylated structures, are being developed to increase drug loading, circulation time, tumor penetration, and efficacy against various solid tumors. Clinical trials are ongoing, including arterial infusion-based therapies for advanced solid tumors and hepatic arterial infusion in liver-directed therapy.

Other names

paclitaxel-loaded cationic liposomepaclitaxel cationic liposomes for injectioncationic liposomal paclitaxel