paclitaxel-eluting stent

**Paclitaxel-eluting stent** refers here to the Boston Scientific **TAXUS Express/TAXUS Express2 Paclitaxel-Eluting Coronary Stent System**, a coronary device-drug combination used during percutaneous coronary intervention. The stainless-steel balloon-expandable coronary stent is coated with a non-erodible Translute triblock copolymer matrix containing paclitaxel. Following implantation, paclitaxel is released locally into the arterial wall, where it binds tubulin and stabilizes microtubules, suppressing vascular smooth-muscle-cell proliferation and neointimal hyperplasia that can cause restenosis. TAXUS Express2 received FDA approval for de novo coronary artery lesions and was also studied and approved in settings including primary PCI for ST-segment elevation myocardial infarction and bare-metal-stent restenosis.

Brand names

TAXUS ExpressTAXUS Express2

Other names

paclitaxel-eluting coronary stentpaclitaxel-eluting stent