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paclitaxel polymeric micelles + fruquintinib
- Development stage
- Phase 2
- Lead developer
- HUTCHMED
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination therapy consisting of paclitaxel polymeric micelles and fruquintinib. Paclitaxel polymeric micelles is a novel formulation of paclitaxel that uses polymeric micelles as a delivery system, eliminating the need for polyoxyethylene castor oil solvent and pretreatment with anti-allergy medications. Fruquintinib is an oral, highly selective VEGFR 1/2/3 inhibitor. This combination has shown promising efficacy in the treatment of advanced gastric cancer and gastroesophageal junction adenocarcinoma as second-line therapy.
- Brand names
- Cynilo
- Other names
- Paclitaxel Polymeric Micelles for Injection combined with Fruquintinib CapsulesPaclitaxel Polymeric Micelles + Fruquintinib
02
Targets
MicrotubuleVEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)TUBB (Tubulin (alpha and beta subunits))
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