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paeoniae radix
- Development stage
- Phase 1
- Lead developer
- Mediplantex
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Paeoniae Radix is a traditional East Asian herbal medicine derived from the dried roots of *Paeonia lactiflora* Pall. or *Paeonia veitchii* Lynch. In Traditional Chinese Medicine (TCM), it is categorized into two primary forms: Paeoniae Radix Alba (White Peony Root), which is typically boiled and peeled, and Paeoniae Radix Rubra (Red Peony Root), which is dried raw. The herb contains a variety of bioactive compounds, most notably the monoterpene glycoside paeoniflorin, along with albiflorin and oxypaeoniflorin. It is widely recognized for its immunomodulatory, anti-inflammatory, and analgesic properties. Clinical applications include the management of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, as well as the treatment of pain, muscle spasms, and gynecological disorders like dysmenorrhea.
- Brand names
- Shaoyao
- Other names
- 芍药shao yaopeony rootpaeonia lactiflora rootradix paeoniaewhite peony rootred peony rootpaeoniae radix albapaeoniae radix rubrabạch thược
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)VCAM1 (Vascular cell adhesion molecule 1)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)NF-κBTNFA (Tumor necrosis factor alpha (soluble))
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