paeoniflorin

Paeoniflorin is a monoterpenoid glycoside and the principal bioactive compound found in the roots of Paeonia species, such as Paeonia lactiflora and Paeonia suffruticosa. It has been used in traditional Chinese medicine for over 2,000 years. Pharmacologically, paeoniflorin exhibits a broad spectrum of activities including anti-inflammatory, antioxidant, immunomodulatory, hepatoprotective, neuroprotective, antiplatelet, hypoglycemic (antidiabetic), antifibrotic, and cardiovascular protective effects[3][5][10]. Its mechanisms involve modulation of multiple signaling pathways such as TLR4-NF-κB (anti-inflammatory), PI3K/Akt/Nrf2 (antioxidant), JAK2/STAT6 (fibrosis inhibition), regulation of glucose metabolism via enhanced insulin sensitivity and secretion[3], inhibition of hepatic stellate cell activation[5], and protection against ischemia-reperfusion injury in neural tissue[7]. Preclinical studies suggest low toxicity with favorable safety profiles. It is under investigation for diabetes management and liver diseases.

Other names

peoniflorinpaeoniflormpaeony root (as source)Delmacinone