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PAiN multimodal analgesia

Development stage
Unknown
Lead developer
St. Antonius Ziekenhuis
Modality
Small Molecules
01

Overview

PAiN multimodal analgesia is a standardized postoperative pain management protocol developed and utilized by St. Antonius Hospital. It is specifically employed for patients undergoing minimally invasive lung surgeries, such as video-assisted thoracoscopic surgery (VATS) or robot-assisted thoracoscopic surgery (RATS). The protocol follows a multimodal approach, combining an intercostal nerve block (local anesthesia), patient-controlled analgesia (PCA, typically involving systemic opioids), and acetaminophen. This combination is designed to optimize pain relief while reducing the total consumption of opioids and minimizing their associated adverse effects, thereby supporting enhanced recovery after surgery (ERAS) goals.

Other names
PAiN - multimodal analgesiaPAIN-St. Antonius Hospital
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NaV (Voltage-gated sodium channels)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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