Painkyl

**Painkyl** is a brand name for fentanyl buccal soluble film, a mucoadhesive formulation designed for rapid transmucosal delivery of fentanyl, an opioid agonist, to manage breakthrough cancer pain in opioid-tolerant adult patients already on around-the-clock opioid therapy. It consists of two layers—a mucoadhesive layer containing fentanyl and an inactive layer to limit oral diffusion—with approximately 50% of the dose absorbed rapidly via the buccal mucosa for high bioavailability and quick onset. Developed using BioDelivery Sciences' BEMA technology and marketed by partners like TTY Biopharm in certain regions, it provides significant pain intensity reduction versus placebo in trials, though typical opioid adverse events such as nausea and vomiting occur.[1][8][9]

Brand names

PainkylOnsolisBreakyl

Other names

fentanyl sublingual tabletrapidly-disintegrating sublingual fentanylAbstral