palm-2-SS-CART(61-102)

palm-2-SS-CART(61-102) is a lipidized (palmitoylated) analogue of the anorexigenic neuropeptide cocaine- and amphetamine-regulated transcript peptide (CARTp), specifically the 61-102 fragment. It features two disulfide bridges (2-SS) to enhance structural stability and in vitro plasma half-life. Developed by researchers at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, the drug acts as an agonist at CART receptors. The palmitoylation modification is intended to improve the peptide's pharmacokinetic profile, including enhanced binding affinity to PC12 cells and the ability to cross the blood-brain barrier. In preclinical studies using mouse models of obesity and Alzheimer's disease, chronic subcutaneous treatment with palm-2-SS-CART(61-102) significantly reduced body weight and food intake, improved metabolic parameters, decreased levels of hyperphosphorylated Tau protein, and increased hippocampal neurogenesis.

Other names

palmitoylated 2-SS-CART(61-102)lipidized CARTp analoguepalmitoylated cocaine- and amphetamine-regulated transcript peptide (61-102) analogue