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Pan-Salmonella-with-Alum vaccine
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Parenteral
01
Overview
**Pan-Salmonella-with-Alum vaccine** is an investigational, alum-adjuvanted quadrivalent vaccine from GSK Vaccines Institute for Global Health designed to prevent invasive disease caused by *Salmonella enterica* serovars Typhi, Paratyphi A, Typhimurium, and Enteritidis. The formulation combines a commercial typhoid conjugate vaccine component, an O:2-CRM197 glycoconjugate component for *S. Paratyphi* A, and GMMA components presenting O-antigens from *S.* Typhimurium and *S.* Enteritidis; alum is included to enhance vaccine immunogenicity. ([sanctr.samrc.ac.za](https://sanctr.samrc.ac.za/TrialDisplay.aspx?TrialID=14967))\n\nThe candidate is being evaluated in the randomized, controlled, observer-blind Phase 1 study NCT07663032/GSK study 300281 in healthy adults aged 18 to 45 years in Africa, with safety, reactogenicity, and immune responses as primary development objectives. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07663032))
- Other names
- GVGH Quadrivalent Pan-Salmonella Vaccine With AlumPan-Salmonella vaccine with AlumPan-Salmonella-with-Alum vaccine
02
Targets
O-antigen polysaccharide of Salmonella Paratyphi AO-antigen (O-antigen polysaccharide of Salmonella Enteritidis)O-antigen (O-antigen polysaccharide of Salmonella Typhimurium)O-Ag (Salmonella enterica O-antigen)Vi antigen (Vi capsular polysaccharide)O9 (Salmonella Enteritidis O-antigen polysaccharide)Salmonella enterica serovar Paratyphi A O:2 O-antigenO-antigen (Salmonella Typhimurium O-antigen polysaccharide)
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