panaxadiol

Panaxadiol is a triterpene sapogenin and a stable saponin derivative originally found in species of Panax (ginseng)[1][2][4]. It belongs to the dammarane-type triterpenoid saponins and is formed during the acid hydrolysis of ginsenosides[4][5][8]. Panaxadiol exhibits a wide range of pharmacological activities, including **anticancer**, **cardioprotective**, **anti-arrhythmic**, antioxidative, and **anti-inflammatory** effects[1][4][6]. Mechanistically, its activities include inhibition of Ca2+ channels and decrease of reactive oxygen species in cardiac models, as well as promotion of apoptosis and inhibition of proliferation in cancer cells[1][3]. It improves the efficacy of chemotherapeutics in animal models by synergizing with drugs like cyclophosphamide[1]. In lung inflammation models, panaxadiol inhibits TNFA/TNFAR and IL7/IL7R signaling, reducing inflammatory cell infiltration and cytokine production[4]. It also promotes the beiging of white adipose tissue and thermogenesis through the β2/cAMP pathway, indicating potential anti-obesity effects[6]. The compound is being researched for potential application in oncology, lung inflammation, obesity, and cardiovascular injury[1][3][4][6].

Brand names

panaxadiol

Other names

PanaxadioPanaxaidolGinseng diolPanaxadiol(AS)(20R)-PanaxadiolPanaxquinquefolium L.DAMMARANE-3BETA,12BETA-DIOL(20R)-20,25-Epoxy-5α-dammarane-3β,12β-diolDammarane-3,12-diol, 20,25-epoxy-(3β,12β,20R)-