panaxytriol

Panaxytriol is an unsaturated fatty alcohol classified as a polyacetylene compound and found naturally in the roots of Panax ginseng—specifically Korean red ginseng[2][3][4][11]. It is a bioactive constituent that has demonstrated significant anti-tumor and anti-inflammatory properties, including inhibition of several human cancer cell lines such as gastric carcinoma, lymphoma, breast carcinoma, and melanoma, in both in vitro and in vivo studies[3][7][9]. Mechanistically, panaxytriol acts in part by inducing phase 2 detoxification enzymes, such as quinone reductase, which contribute to cytoprotection against toxic insults and chemoprevention by promoting cellular defense responses to electrophiles and oxidative stress[1][3][5][7]. Additional activities include modulation of cytochrome P450 3A enzymes (CYP3A), affecting drug metabolism and possibly chemotherapeutic tolerance[2][5]. Panaxytriol has moderate neurotrophic activity and minimal toxicity at cytoprotective doses; analogs of the compound have exhibited increased potency without increased toxicity[3][9].

Other names

panaxytriol1-heptadecene-4,6-diyne-3,9,10-triolheptadec-1-en-4,6-diyne-3,9,10-triolfalcarintriol