Drug intelligence / Profile preview

Panblok H7 + MF59

Development stage
Phase 2
Lead developer
Parent
Modality
Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Intramuscular
01

Overview

Panblok H7 + MF59 is a combination vaccine consisting of the recombinant hemagglutinin (rHA) antigen from the influenza A/H7 virus (Panblok H7) formulated with the oil-in-water emulsion adjuvant MF59. The vaccine is designed to induce an immune response against avian-origin influenza A(H7N9) and related strains. The addition of the MF59 adjuvant enhances immunogenicity by promoting stronger antibody responses and enabling antigen dose sparing compared to unadjuvanted formulations. Mechanistically, the rHA component elicits neutralizing antibodies targeting viral hemagglutinin, while the MF59 adjuvant acts by recruiting immune cells to the injection site and enhancing antigen presentation through induction of chemokines and cytokines[1][2][3]. This combination has been evaluated in clinical trials for safety and immunogenicity in adults across various age groups[1][3][4].

Brand names
Panblok H7 + MF59
Other names
recombinant H7 influenza vaccine adjuvanted with MF59Panblok + MF59
02

Targets

HA (Hemagglutinin)

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