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PanChol
- Development stage
- Phase 1
- Lead developer
- Mass General Brigham
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Oral, Injectable
01
Overview
PanChol is a single-dose, live-attenuated oral cholera vaccine (OCV) derived from a seventh-pandemic *Vibrio cholerae* O1 strain. It is genetically engineered to co-express both Inaba and Ogawa antigens and to over-express the non-toxic cholera toxin B subunit (CTB). Additionally, the vaccine targets the toxin-coregulated pilus (TCP), a critical factor for intestinal colonization. PanChol is designed to minimize reactogenicity and be incapable of toxigenic reversion, addressing the limitations of current killed whole-cell vaccines that require multiple doses and show reduced efficacy in children. Clinical data from Phase 1 trials indicate that PanChol is safe, well-tolerated, and highly immunogenic, inducing 100% vibriocidal seroconversion across a wide dose range in healthy adults.
- Other names
- PanChol
02
Targets
O-antigen (Salmonella Typhimurium O-antigen polysaccharide)
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