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Pancreate
- Development stage
- Phase 1
- Lead developer
- Nanomix
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
Pancreate (proisletide acetate) is a first-in-class bioactive peptide developed by CureDM, previously in collaboration with Sanofi. It is a synthetic version of a naturally occurring human peptide sequence known as HIP-2B (Human Islet Peptide 2B), which is derived from the Regenerating (REG) protein family. Pancreate is designed to stimulate the differentiation of pancreatic progenitor cells into functional, insulin-producing neo-islets. This regenerative approach aims to restore endogenous insulin production and glucose homeostasis in patients with type 1 and type 2 diabetes, potentially offering a disease-modifying alternative to exogenous insulin therapy. Although the drug reached early clinical trials, development was largely discontinued after Sanofi terminated its licensing agreement with CureDM in 2014.
- Brand names
- Pancreate
- Other names
- proisletide acetateproisletideHuman Islet Peptide 2B
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)FOXO1 (Forkhead box protein O1)MEN1 (Menin)
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