Drug intelligence / Profile preview

pancreatin + oryz-aspergillus enzyme + acarbose + metformin + glimepiride + insulin

Development stage
Preclinical
Lead developer
Changhai Hospital
Modality
Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral, Subcutaneous
01

Overview

This is not a distinct, co-formulated drug product or a named regimen. It is a non-specific conservative-treatment intervention label from a Changhai Hospital clinical study of painless chronic pancreatitis, combining pancreatic-enzyme replacement options with glucose-lowering medicines used as clinically indicated for pancreatic exocrine and endocrine insufficiency. The source intervention wording presents pancreatin enteric-coated capsules or an oryz-aspergillus enzyme plus pancreatin tablet as alternative enzyme products, and lists acarbose, metformin, glimepiride, and insulin as antidiabetic medicines; it does not establish that all six substances are supplied together or administered to every participant. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07074379))

Other names
pancreatin + oryz-aspergillus enzyme + acarbose + metformin + glimepiride + insulin
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)LIPF (Gastric lipase)INSR (Insulin receptor)SUR1 (Sulfonylurea receptor 1)AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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