pancrelipase (Janssen Pharmaceutical, a47f63)

Pancrelipase is a purified enzyme mixture derived from porcine pancreatic glands, containing **lipase, protease, and amylase**. It is used as **pancreatic enzyme replacement therapy** (PERT) to aid digestion in individuals with exocrine pancreatic insufficiency (EPI), such as that due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions. Mechanistically, pancrelipase works by supplementing the body's digestive enzymes, catalyzing the breakdown of fats (via lipase), proteins (via protease), and carbohydrates (via amylase) in the small intestine, thereby improving nutrient absorption, nutritional status, and gastrointestinal symptoms[1][2][3][5][6][8].

Brand names

CREONZenpepPancreazePertzyeUltresaViokacePancrexPancreatinPancreasePanlipase

Other names

pancreatic extract pancrelipasepancreatinumpancreatinpancreatic protease