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pancrelipase (Sunnybrook Health Sciences Centre)
- Development stage
- Unknown
- Lead developer
- Sunnybrook Health Sciences Centre
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Oral
01
Overview
Pancrelipase is a combination of porcine-derived digestive enzymes, including lipase, amylase, and protease, used as pancreatic enzyme replacement therapy (PERT). It is indicated for the treatment of pancreatic exocrine insufficiency (PEI) associated with conditions such as cystic fibrosis, chronic pancreatitis, and pancreatic surgery. Sunnybrook Health Sciences Centre is conducting the PERQ-UP pilot randomized controlled trial to evaluate the feasibility and efficacy of initiating PERT immediately following pancreaticoduodenectomy (Whipple procedure) to improve patient quality of life and nutritional outcomes, compared to the standard of care where PERT is only started upon the development of clinical symptoms.
- Brand names
- CreonZenpepPancreazePertzyeViokace
- Other names
- pancreatic enzyme replacement therapyPERTpancreatin
02
Targets
PNLIP (Pancreatic triacylglycerol lipase)AMY (Pancreatic alpha-amylase)
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