Drug intelligence / Profile preview

pancrelipase + Ensure Plus

Development stage
Unknown
Lead developer
Janssen Pharmaceutical
Modality
Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

"pancrelipase + Ensure Plus" represents a therapeutic combination of a drug, pancrelipase, and a medical nutritional supplement, Ensure Plus. Pancrelipase is a pancreatic enzyme replacement therapy (PERT) composed of a mixture of lipases, proteases, and amylases derived from porcine pancreas. It is administered orally to treat exocrine pancreatic insufficiency (EPI), a condition where the pancreas fails to produce enough digestive enzymes, which is often associated with cystic fibrosis, chronic pancreatitis, or pancreatectomy. The enzymes in pancrelipase help to break down fats, proteins, and carbohydrates from food in the duodenum, thereby improving digestion and nutrient absorption. Ensure Plus is a high-calorie, high-protein, ready-to-drink oral nutritional supplement designed for individuals experiencing malnutrition, at nutritional risk, or with involuntary weight loss. It provides a concentrated source of calories, protein, and 27 essential vitamins and minerals to help patients gain or maintain a healthy weight. The combined use of pancrelipase and a nutritional supplement like Ensure Plus is a common management strategy for conditions like EPI, where both enzymatic support for digestion and enhanced nutritional intake are crucial to prevent malnutrition and manage symptoms like steatorrhea (fatty stools).

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