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Drug intelligence / Profile preview
Pandrate DSR
- Development stage
- Phase 4
- Lead developer
- Suncure Lifescience
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pandrate DSR is a branded generic oral combination medication developed and marketed by Suncure Lifescience. It consists of pantoprazole (40 mg), a proton pump inhibitor, and domperidone (10 mg), a dopamine D2 receptor antagonist. Pantoprazole reduces gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell. Domperidone acts as a prokinetic agent by antagonizing dopamine D2 receptors in the gastrointestinal tract, which increases lower esophageal sphincter tone and enhances gastric emptying. This combination is indicated for the management of gastro-oesophageal reflux disease (GERD) and dyspepsia, particularly when symptoms are associated with nausea or delayed gastric emptying.
- Brand names
- Pandrate DSR
02
Targets
KCNH2 (Voltage-gated potassium channel subfamily H member 2)ATP4A (Potassium–transporting ATPase alpha chain 1)ATP4B (Potassium-transporting ATPase subunit beta)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)
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