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**Pangramin Depot UM** is a biologically standardized **depot allergen immunotherapy extract** derived from *Dermatophagoides pteronyssinus* house-dust mite and adsorbed onto **aluminum hydroxide** for sustained subcutaneous administration. It was used as a therapeutic desensitization product in patients with respiratory allergy, including perennial rhinitis and mild to moderate bronchial asthma, with quantified major allergens **Der p 1** and **Der p 2**. Its therapeutic effect is based on **allergen-specific immunotherapy**, in which repeated exposure to mite allergens aims to induce immune tolerance and reduce IgE-mediated hypersensitivity symptoms rather than directly blocking a single receptor or enzyme. The cited publication supports use in house-dust mite allergy, but the specific commercial developer and manufacturer are not clearly identifiable from the provided source alone.
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