Drug intelligence / Profile preview

Pangramin Depot UM

Development stage
Preclinical
Lead developer
ALK Abelló
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

**Pangramin Depot UM** is a biologically standardized **depot allergen immunotherapy extract** derived from *Dermatophagoides pteronyssinus* house-dust mite and adsorbed onto **aluminum hydroxide** for sustained subcutaneous administration. It was used as a therapeutic desensitization product in patients with respiratory allergy, including perennial rhinitis and mild to moderate bronchial asthma, with quantified major allergens **Der p 1** and **Der p 2**. Its therapeutic effect is based on **allergen-specific immunotherapy**, in which repeated exposure to mite allergens aims to induce immune tolerance and reduce IgE-mediated hypersensitivity symptoms rather than directly blocking a single receptor or enzyme. The cited publication supports use in house-dust mite allergy, but the specific commercial developer and manufacturer are not clearly identifiable from the provided source alone.

Brand names
Pangramin Depot UM
Other names
Dermatophagoides pteronyssinus depot allergen extractD. pteronyssinus depot extracthouse-dust mite allergen extract
02

Targets

Der p 2 (Dermatophagoides pteronyssinus allergen 2)Der p 1 (Dermatophagoides pteronyssinus allergen 1)

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