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Pantera Lux
- Development stage
- Unknown
- Lead developer
- Biotronik
- Modality
- Small Molecules
- Administration
- Intra-arterial, Percutaneous
01
Overview
Pantera (specifically Pantera Lux) is a paclitaxel-eluting drug-coated balloon (DCB) catheter developed by Biotronik. It is a drug-device combination used in interventional cardiology to treat coronary artery disease, specifically in-stent restenosis (ISR) and ST-segment elevation myocardial infarction (STEMI). The device delivers a 3.0 µg/mm² dose of paclitaxel, a taxane that inhibits neointimal proliferation by stabilizing microtubules and preventing smooth muscle cell division. The balloon surface utilizes butyryltri-n-hexyl citrate (BTHC) as an excipient to optimize the transfer and retention of paclitaxel in the vessel wall. Clinical evaluations, including trials coordinated by Diagram B.V., have investigated its efficacy as a pre-dilatation tool prior to stent implantation to reduce restenosis rates.
- Brand names
- Pantera LuxPantera
- Other names
- paclitaxel-eluting balloondrug-coated balloonDEBDCB
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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