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panthenol + centella asiatica extract
- Development stage
- Unknown
- Lead developer
- Hospital de Clínicas Dr. Manuel Quintela
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Panthenol + centella asiatica extract is a topical combination formulation containing panthenol (provitamin B5) and Centella asiatica (cica) extract. It is primarily used as a skin-protective, soothing, and regenerating emollient. Panthenol acts as a humectant and skin-conditioning agent that improves stratum corneum hydration, reduces transepidermal water loss, and accelerates re-epithelialization. Centella asiatica extract, rich in active compounds like madecassoside, promotes collagen synthesis, exerts anti-inflammatory and antioxidant effects, and supports wound healing. This combination is being clinically evaluated for the prevention and mitigation of radiation-induced skin toxicity (radiodermatitis) in breast cancer patients undergoing adjuvant radiotherapy.
- Other names
- dexpanthenol + centella asiatica extractdexpanthenol + cicapanthenol + centella asiaticapanthenol + cicaprovitamin B5 + centella asiatica extract
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CD14 (Monocyte differentiation antigen CD14)Cr (Chromium)Gtf (Streptococcus mutans glucosyltransferase)MC1R (Melanocortin Type 1 Receptor)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT3 (Signal Transducer and Activator of Transcription 3)TLR4 (Toll-like receptor 4)CLEC7A (Dectin-1)
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