Drug intelligence / Profile preview

Panzytrat

Development stage
Unknown
Lead developer
Allergan
Modality
Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
Administration
Oral
01

Overview

Panzytrat is a pancreatic enzyme replacement therapy (PERT) containing pancrelipase, a porcine-derived preparation of essential digestive enzymes including lipase, amylase, and protease. It is specifically indicated for the treatment of exocrine pancreatic insufficiency (EPI) associated with conditions such as cystic fibrosis, chronic pancreatitis, and post-pancreatic surgery. The drug is formulated as enteric-coated microtablets within a capsule, designed to protect the enzymes from gastric acid degradation and ensure their release in the alkaline environment of the duodenum. By supplementing the patient's deficient endogenous enzymes, Panzytrat facilitates the hydrolysis of fats into fatty acids and glycerol, carbohydrates into dextrins and sugars, and proteins into peptides and amino acids, thereby reducing malabsorption and associated symptoms like steatorrhea.

Brand names
PanzytratPanzytrat 25,000Panzytrat 10,000
Other names
pancrelipasepancreatinpancreatic enzymes
02

Targets

PNLIP (Pancreatic triacylglycerol lipase)AMY (Pancreatic alpha-amylase)

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