para-iodo-D-phenylalanine hydroxamic acid

Para-Iodo-D-Phenylalanine Hydroxamic Acid is a synthetic small molecule and an analog of D-phenylalanine, in which the para position of the phenyl ring is substituted with an iodine atom and the carboxylic acid group is converted to a hydroxamic acid. It has been primarily studied as a biochemical tool and as an inhibitor of metalloproteases, specifically aminopeptidases. Structural studies have shown that it acts as a potent inhibitor by chelating zinc ions at the active site of enzymes such as Aeromonas proteolytica aminopeptidase, stabilizing enzyme-inhibitor complexes through its hydroxamate moiety[9]. There are no known clinical indications or approved therapeutic uses for this compound; it remains experimental and is mainly used in structural biology and enzymology research[4][9].

Other names

(2R)-2-amino-N-hydroxy-3-(4-iodophenyl)propanamideN-hydroxy-4-iodo-D-phenylalaninamideN-hydroxy4-iodo-D-phenylalaninamideN-hydroxy 4-iodo-D-phenylalaninamide