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Parabacteroides distasonis
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Parabacteroides distasonis is a Gram-negative anaerobic bacterium that is a natural resident of the human gut microbiota. It is being developed as a next-generation probiotic or live biotherapeutic product (LBP) for various diseases. The bacterium itself is the active ingredient, exerting its effects by producing a range of metabolites, including nicotinic acid, succinate, and short-chain fatty acids (SCFAs). These metabolites interact with host systems by targeting pathways such as the intestinal GPR109a receptor and PPARα signaling. Additionally, P. distasonis is recognized for its immunomodulatory properties; outer membrane vesicles (Pd-OMVs) derived from the bacterium are being explored as potential immunostimulants for cancer immunotherapy by modulating CXCL10 and CD8+ T cell responses. Research institutions are investigating its therapeutic potential in metabolic and gastrointestinal diseases, including obesity, type 2 diabetes, inflammatory bowel disease, and various cancers.
- Other names
- P. distasonis
02
Targets
FXR (Farnesoid x-activated receptor)GLP1R (GLP-1R)PPARA (Peroxisome proliferator-activated receptor alpha)CXCL10 (C-X-C Motif Chemokine Ligand 10)HCAR2 (Hydroxycarboxylic acid receptor 2)
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