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paracetamol + chlorphenamine
- Development stage
- Unknown
- Lead developer
- Abiogen
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Paracetamol + chlorphenamine is a fixed-dose combination medication comprising the analgesic and antipyretic paracetamol (acetaminophen) and the first-generation H1-antihistamine chlorphenamine (chlorpheniramine) maleate. Paracetamol exerts its effects primarily through the inhibition of prostaglandin synthesis in the central nervous system, reducing pain and fever. Chlorphenamine acts as a competitive antagonist at the H1 histamine receptor, alleviating symptoms of allergic reactions and the common cold, such as rhinorrhea and sneezing. This combination is widely utilized as an over-the-counter (OTC) treatment for symptomatic relief of cold and flu symptoms, including headache, fever, and nasal congestion.
- Other names
- paracetamol + chlorphenamine maleateacetaminophen + chlorpheniramineparacetamol + chlorpheniramine
02
Targets
mAChR (Muscarinic acetylcholine receptors)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)
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