paracetamol + dipyrone + tramadol

This standard care treatment refers to a multi-modal analgesic regimen utilized as the control arm in clinical research conducted by the Tel-Aviv Sourasky Medical Center for patients with blunt thoracic trauma and lung contusion. The protocol is designed to manage pain and serve as a baseline therapy for evaluating the efficacy of experimental anti-inflammatory agents in preventing acute lung injury (ALI). The regimen consists of a combination of three active ingredients: paracetamol (acetaminophen), dipyrone (metamizole), and tramadol. Paracetamol and dipyrone provide non-opioid analgesia and antipyretic effects primarily through the inhibition of cyclooxygenase enzymes, while tramadol provides moderate-strength opioid analgesia via mu-opioid receptor agonism and the inhibition of serotonin and norepinephrine reuptake. This combination targets multiple pain pathways to optimize patient comfort following thoracic injury.

Brand names

Tramal

Other names

standard care treatmentanalgesia with paracetamol/dypiron/tramalstandard care treatment-Tel-Aviv Sourasky Medical Center-acute lung injury