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paracetamol + ibuprofen + metamizol-Medical University of Warsaw-acute pancreatitis-acute pain
- Development stage
- Unknown
- Lead developer
- Medical University of Warsaw
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This entry refers to a Phase 4 clinical trial (NCT05493280) conducted by the Medical University of Warsaw to evaluate non-opioid analgesic strategies for acute pain management in pediatric patients with acute pancreatitis. The trial compares two distinct intravenous combination regimens: paracetamol plus ibuprofen and paracetamol plus metamizole. Paracetamol is a non-opioid analgesic and antipyretic; ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2); and metamizole (dipyrone) is a pyrazolone derivative with analgesic, antipyretic, and spasmolytic properties. The study aims to assess the effectiveness and tolerance of these combinations over a 48-hour period to optimize pain control while minimizing opioid use in children.
- Brand names
- Paracetamol B. BraunParacetamol KabiIbuprofen B. BraunIbuprofen KabiMetamizol-SFMetamizole KabiPyralgin
- Other names
- Paracetamol with Ibuprofen vs Metamizole for Pediatric Acute Pancreatitis Pain
02
Targets
COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)PGHS-1 (Prostaglandin G/H Synthase 1)
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