Drug intelligence / Profile preview

paracetamol + meloxicam

Development stage
Unknown
Lead developer
Aristo Pharmaceuticals
Modality
Small Molecules
Administration
Oral, Intramuscular, Intravenous
01

Overview

**Paracetamol + meloxicam** is an oral fixed-dose analgesic combination containing paracetamol, also called acetaminophen, and meloxicam. Meloxicam is an oxicam nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase-mediated prostaglandin synthesis, while paracetamol provides analgesic and antipyretic activity through a mechanism thought to act primarily in the central nervous system. Marketed tablet presentations include 7.5 mg meloxicam plus 325 mg paracetamol and are used for pain and inflammation associated with musculoskeletal conditions, including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. ([1mg.com](https://www.1mg.com/drugs/melodol-tablet-302959))

Brand names
MelodolPaincon Forte
Other names
acetaminophen + meloxicammeloxicam + acetaminophenmeloxicam + paracetamolparacetamol + meloxicam
02

Targets

COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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